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Dota: Dragon’s Blood doesn’t seem to adapt the game directly. Instead, based on the information provided in the game and the TV show, the series is more of a prequel. This isn’t confirmed, but based on information known about the Dragon Knight, Slyrak, and the war, a prequel makes the most sense.
However, there are many character overlaps, including the Oracle, the Terrorblade, the Dragon Knight, Mirana, Marci, Luna, and The Winter Wyvern.