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8 Best Hypochlorous Acid Sprays 2025, Reviewed By Experts


Your hypochlorous acid FAQs, answered:


What is hypochlorous acid?

“Hypochlorous acid (HOCl) is naturally produced by your white blood cells to combat infection and bacteria,” explains Jennifer Buron, Head of Spa, Clinic and Development at Hyclo Skin.

“A key part of the body’s immune response, it helps to defend against environmental stressors, and support skin recovery,” adds Megan Picurro, Director of Marketing at Mario Badescu Skin Care. So, it’s not all that surprising that it’s quickly become such a must-have skincare ingredient.


What does a hypochlorous acid spray do for the skin?

Put simply, hypochlorous acid helps to purify and soothe the skin — making it a popular choice for a post-workout spritz. “It helps cleanse the skin’s surface of potential breakout-causing bacteria, reduce the appearance of redness, and keep the skin feeling balanced,” Picurro adds.

Great for tackling any kind of redness or irritation on the face, hypochlorous acid can also be used to soothe sunburn, itchy bug bites, and post-shaving bumps anywhere else on the body. “Essentially, it supports wound healing, and helps strengthen the skin barrier for a healthier and more resilient complexion,” says Buron.

“Crucially, hypochlorous acid is a game-changer for sensitive and problematic skin,” adds David Connor, Co-Founder of Kanzen Skincare. “Because of its naturally antibacterial and anti-inflammatory properties, it’s ideal for acne-prone skin, rosacea, eczema, and general irritation.”

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Can you use a hypochlorous spray every day?

Yes! In fact — because it’s non-toxic and alcohol-free — you’re likely fine to use it multiple times a day. “It doesn’t disrupt the skin’s natural microbiome, so can be used as a refreshing mist, a post-cleansing toner, or to calm inflammation and irritation,” Buron explains.

Top tip? Store your chosen mist in the skincare fridge to keep it lovely and cool, and enjoy a refreshing spritz when needed.


Are there any potential side effects worth knowing about?

Generally, no. According to Picurro, some people might feel a “slight tingle” when it’s first applied — but that’s normal, and the sensation generally fades pretty quickly.

“When applied to certain skin concerns, HOCl can sometimes make things look worse at first before they start to get better,” Buron adds. “If this happens, make sure you’re pairing your spray with a light moisturiser to help maintain balance and hydration.”


What specific skincare ingredients shouldn’t be used alongside hypochlorous acid?

“You should avoid using hypochlorous acid with strong exfoliants like lactic acid, glycolic acid, and salicylic acid, as this could increase the risk of irritation,” David Connor explains. Similarly, active ingredients like retinol and vitamin C can effect the pH balance of the skin — creating a more alkaline environment — which can reduce the effectiveness of hypochlorous acid. So stick to using them at different times of the day if possible.

Ideally, apply your hypochlorous acid straight after your cleanser, and let it dry for a minute or so before carrying on with your skincare routine. “Hypochlorous acid works best when applied first before heavier serums or occlusives to allow its soothing and antimicrobial benefits to take full effect,” Connor adds.

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